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INFRAFRONTIER-EMMA, MONTEROTONDO MOUSE CLINIC

CNR has established and developed at the A. Buzzati Traverso Campus, Monterotondo the European Mouse Mutant Archive (EMMA) and Monterotondo Mouse Clinic (MMC) international network infrastructures for the life sciences. They are devoted to the large-scale, standardized production, primary phenotypic analysis, cryopreservation and dissemination of novel murine mutant models of human diseases and their bioinformatic resources.

EMMA and MMC are essential component of the Infrafrontier infrastructure project, which has been selected by European Strategy Forum on Research Infrastructures (ESFRI) Roadmap, the Italian Ministry of Research?s Roadmap on Pan -European Infrastructures and other national Roadmaps.

The Monterotondo Mouse Clinic project is linked to Infrafrontier's main mission on systemic phenotyping and fits in the International Mouse Phenotyping Consortium (IMPC) global initiative, which Italy has joined in 2013.

The INFRAFRONTIER-EMMA infrastructure is selectively supported by CNR, as detailed in the Activity Plan 2016-2018 (in Italian).

http://www.urp.cnr.it/copertine/ente/ente_normativa/ordinamento/2016/052.pdf

External links:
www.infrafrontier.eu 
www.emma.cnr.it/CNR-Monterotondo.html
https://ec.europa.eu/research/infrastructures/index_en.cfm?pg=what
http://www.mousephenotype.org

 

 

 

  • Personnel involved

  • Selected publications

de Angelis MH, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl MR, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, Fertak LE, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Wattenhofer-Donze M, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A; EUMODIC Consortium, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD.
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
Nat Genet. 2015; 47(9):969-78.

Karp N.A.; Meehan T.F.; Morgan H.; Mason J.C.; Blake A.; Kurbatova N.; Smedley D.; Jacobsen J.; Mott R.F.; Iyer V.; Matthews P.; Melvin D.G.; Wells S.; Flenniken A.M.; Masuya H.; Wakana S.; White J.K.; Lloyd K.C.K.; Reynolds C.L.; Paylor R.; West D.B.; Svenson K.L.; Chesler E.J.; de Angelis M.H.; Tocchini-Valentini G.P.; Sorg T.; Herault Y.; Parkinson H.; Mallon A.-M.; Brown S.D.M.
Applying the ARRIVE Guidelines to an In Vivo Database
PLoS Biol. 2015; 13(5):e1002151.

Gina La Sala*, Daniela Marazziti*, Chiara Di Pietro, Elisabetta Golini, Rafaele Matteoni and Glauco P. Tocchini-Valentini
Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor
FASEB J. 2015; 29(5):2059-69.

Maggi S, Garbugino L, Heise I, Nieus T, Balci F, Wells S,  Tocchini-Valentini GP, Mandillo  S, Nolan PM, Tucci V.
A Cross-Laboratory Investigation of Timing Endophenotypes in Mouse Behavior

Steve Brown on behalf of 22 co-signatories of the International Mouse Phenotyping Consortium (Glauco Tocchini-Valentini)
Animal models: Mouse already being charted gene by gene
Nature. 2014; 508(7496):319.

Mandillo SHeise IGarbugino LTocchini-Valentini GPGiuliani AWells SNolan PM.
Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation.
Dis Model Mech. 2014;7(3):397-407.

INFRAFRONTIER Consortium (Mehaan TF. et al. ... Massimi M., Matteoni R., Tocchini-Valentini GP. ...)
INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community
Nucleic Acids Res. 2015;43(Database issue)

Simon MMGreenaway SWhite JKFuchs HGailus-Durner VWells SSorg TWong KBedu ECartwright EJDacquin RDjebali SEstabel JGraw JIngham NJJackson IJLengeling AMandillo SMarvel JMeziane HPreitner FPuk ORoux MAdams DJAtkins SAyadi ABecker LBlake ABrooker DCater HChampy MFCombe RDanecek Pdi Fenza AGates HGerdin AKGolini EHancock JMHans WHölter SMHough TJurdic PKeane TMMorgan HMüller WNeff FNicholson GPasche BRoberson LARozman JSanderson MSantos LSelloum MShannon CSouthwell ATocchini-Valentini GPVancollie VEWesterberg HWurst WZi MYalcin BRamirez-Solis RSteel KPMallon AMde Angelis MHHerault YBrown SD.
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.
Genome Biol. 2013;14(7)

Putti SCalandra PRossi NScarabino DDeidda GTocchini-Valentini GP.
Highly efficient, in vivo optimized, archaeal endonuclease for controlled RNA splicing in mammalian cells.
FASEB J. 2013;27(9):3466-77.

Mandillo S,  Golini E, Marazziti D, Di Pietro C, Matteoni R, Tocchini-Valentini GP.
Mice lacking the Parkinson's related GPR37/PAEL receptor show non-motor behavioral phenotypes: age and gender effect
Genes Brain Behav. 2013;12(4):465-77

Marazziti DDi Pietro CGolini EMandillo SLa Sala GMatteoni RTocchini-Valentini GP.
Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor.
Proc Natl Acad Sci U S A. 2013; 110(41):16486-91.

Tocchini-Valentini GD1, Tocchini-Valentini GP.
Avatar pre-tRNAs help elucidate the properties of tRNA-splicing endonucleases that produce tRNA from permuted genes.
Proc Natl Acad Sci U S A. 2012; 109(52):21325-9.

Tocchini-Valentini GPTocchini-Valentini MA.
Comparative anatomy: Giorgione's Venus, Connoisseur Morelli, and the Reverend Bayes.
FASEB J. 2012 Jan;26(1):5-8.

Daniel J. Klionsky and 1269 others (Chiara Di Pietro*; Daniela Marazziti*; Rafaele Matteoni*; Glauco P. Tocchini Valentini*)
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy. 2008; 4(2):151-75

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.
The mammalian gene function resource: the International Knockout Mouse Consortium.
Mamm Genome. 2012;23(9-10):580-6.

Marazziti DDi Pietro CMandillo SGolini EMatteoni RTocchini-Valentini GP.
Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, DeltaFosB expression, and conditioned place preference to amphetamine and cocaine.
FASEB J. 2011; 25(6):2071-81

Tocchini-Valentini GD, Fruscoloni P,  Tocchini-Valentini GP.
Evolution of introns in the archaeal world.
Proc Natl Acad Sci U S A. 2011; 108(12):4782-7

Di Segni GGastaldi S,  Zamboni MTocchini-Valentini GP.
Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level.
Proc Natl Acad Sci U S A. 2011; 108(41):17082-6.